Drugs + Depressed Teens = A Dangerous Combination
By Psych Central News Editor
Reviewed by John M. Grohol, Psy.D. on May 9, 2008 Friday, May 9 (Psych Central) --
U.S. teenagers who attempt to self-medicate through the use of marijuana or other drugs can end up worsening their depression, says a new report. The report suggests that such drug use could also lead a teen toward other serious mental disorders.
The report cites research which it says shows that some teens are using drugs to alleviate feelings of depression (”self-medicating”), when in fact, using marijuana can compound the problem. The report found, for instance, that teenagers who smoke marijuana at least once a month are three times more likely to have suicidal thoughts than non-users.
The report, from the White House Office of National Drug Control Policy (ONDCP), suggests that up to two million teens felt depressed at some point during the past year, and depressed teens are more than twice as likely as non-depressed teens to have used marijuana during that same period.
Depressed teens are also almost twice as likely to have used illicit drugs as non-depressed teens. They are also more than twice as likely as their peers to abuse or become dependent on marijuana. Marijuana use is associated with depression, suicidal thoughts, and suicide attempts.
“Marijuana is not the answer. Too many young people are making a bad situation worse by using marijuana in a misguided effort to relieve their symptoms of depression,” said John P. Walters, Director, National Drug Control Policy.
“Parents must not dismiss teen moodiness as a passing phase. Look closely at your teen’s behavior because it could be a sign of something more serious.”
Although marijuana use among teens has dropped by 25 percent since 2001, more teens use marijuana than all other illicit drugs combined. The new report, Teen Marijuana Use Worsens Depression: An Analysis of Recent Data Shows ‘Self-Medicating’ Could Actually Make Things Worse (PDF), also found the following:
Using marijuana can lead to depression and other mental illnesses;
The percentage of depressed teens is equal to the percentage of depressed adults, but depressed teens are more likely than depressed adults to use marijuana and other illicit drugs;
Teen girls who use marijuana daily are more likely to develop depression than girls who do not use marijuana;
Depressed teens are also more likely than non-depressed teens to engage in other risky behaviors such as daily cigarette use and heavy alcohol use.
“Don’t be fooled into thinking that pot is harmless,” said Dr. Drew Pinksy, internist, addiction expert, and host of VH1’s Celebrity Rehab. “Marijuana is an addictive drug. Teens who are already depressed and use marijuana may increase their odds of suffering from even more serious mental health problems.”
In fact, the potency of smoked marijuana has risen consistently over the past decades and higher potency translates into serious health consequences for teens. Some studies show that higher potency marijuana may be contributing to an increase in the number of American teens seeking treatment for marijuana dependence.
The risks associated with recent and long-term marijuana use include schizophrenia, other forms of psychosis, and even suicide. “Not only are adolescents at greater risk for drug abuse, but they may suffer more consequences,” said Nora D. Volkow, M. D., Director of the National Institute on Drug Abuse. “There is also some evidence that in vulnerable teens-because of genetic factors-the abuse of marijuana can trigger a schizophreniform disorder.”
The report was released to coincide with May’s Mental Health Awareness Month.
Source: U.S. National Drug Control Policy
Friday, February 13, 2009
Sunday, February 8, 2009
Teen Smoking Could Lead to Adult Depression
Teen Smoking Could Lead To Adult Depression, Study Says
ScienceDaily (Feb. 6, 2009) — Teenagers who smoke could be setting themselves up for depression later in life, according to a groundbreaking new Florida State University study.
Psychology Professor Carlos Bolanos and a team of researchers found that nicotine given to adolescent rats induced a depression-like state characterized by a lack of pleasure and heightened sensitivity to stress in their adult lives. The findings suggest that the same may be true for humans.
"This study is unique because it is the first one to show that nicotine exposure early in life can have long-term neurobiological consequences evidenced in mood disorders," Bolanos said. "In addition, the study indicates that even brief exposure to nicotine increases risk for mood disorders later in life."
The Florida State researchers injected adolescent rats twice daily with either nicotine or saline for 15 days. After the treatment period ended, they subjected the rats to several experiments designed to find out how they would react to stressful situations as well as how they would respond to the offering of rewards.
They found that behavioral changes symptomatic of depression can emerge after one week of nicotine cessation and -- most surprising -- that even a single day of nicotine exposure during adolescence can have long-lasting effects.
"Some of the animals in our study were exposed to nicotine once and never saw the drug again," Bolanos said. "It was surprising to us to discover that a single day of nicotine exposure could potentially have such long-term negative consequences."
The rats that were exposed to nicotine engaged in behaviors symptomatic of depression and anxiety, including repetitive grooming, decreased consumption of rewards offered in the form of sugary drinks and becoming immobile in stressful situations instead of engaging in typical escape-like behaviors. The researchers were able to alleviate the rats' symptoms with antidepressant drugs or, ironically, more nicotine.
Interestingly, adult rodents that were exposed to the same nicotine regimen as the adolescents did not display depression-like traits. It is not known exactly how nicotine works on the brain and nervous system to induce these effects, but exposure has toxic effects in several brain regions and neurotransmitter systems at distinct periods of development, Bolanos said.
Because various neurotransmitter systems in the brain continue to develop throughout adolescence, the researchers theorize that nicotine may negatively influence these systems resulting in altered functionality later in life. The study's findings underscore the need for further research into how this process occurs.
Scientists have long known there is a connection between smoking and mood disorders, but they have not been able to say for sure that one causes the other because there are so many factors influencing human behavior. This study provides support for the idea that smoking can induce symptoms of depression, and paradoxically, can also be a way of managing those same symptoms and enhancing the risk for addiction.
"The message to young people of course is don't smoke and don't even try it," Bolanos said. "If they do smoke, they need to be aware of the potentially long-term effects that recreational or even occasional cigarette smoking can have on their systems."
The work was supported by grants from the state of Florida's James and Esther King Biomedical Research Program and the National Institute on Drug Abuse. In addition, Iniguez has a McKnight Fellowship from the Florida Education Fund and a Neuroscience Fellowship from Florida State University. Warren also is supported by a Neuroscience Fellowship.
Journal reference:
Iñiguez et al. Nicotine Exposure During Adolescence Induces a Depression-Like State in Adulthood. Neuropsychopharmacology, 2008; DOI: 10.1038/npp.2008.220
Adapted from materials provided by Florida State University.
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Tuesday, February 3, 2009
What happens to your brain when you take drugs?
What happens to your brain when you take drugs?
Drugs are chemicals that tap into the brain's communication system and disrupt the way nerve cells normally send, receive, and process information. There are at least two ways that drugs are able to do this: (1) by imitating the brain's natural chemical messengers, and/or (2) by overstimulating the "reward circuit" of the brain.
Some drugs, such as marijuana and heroin, have a similar structure to chemical messengers, called neurotransmitters, which are naturally produced by the brain. Because of this similarity, these drugs are able to "fool" the brain's receptors and activate nerve cells to send abnormal messages.
Other drugs, such as cocaine or methamphetamine, can cause the nerve cells to release abnormally large amounts of natural neurotransmitters, or prevent the normal recycling of these brain chemicals, which is needed to shut off the signal between neurons. This disruption produces a greatly amplified message that ultimately disrupts normal communication patterns.
Nearly all drugs, directly or indirectly, target the brain's reward system by flooding the circuit with dopamine. Dopamine is a neurotransmitter present in regions of the brain that control movement, emotion, motivation, and feelings of pleasure. The overstimulation of this system, which normally responds to natural behaviors that are linked to survival (eating, spending time with loved ones, etc), produces euphoric effects in response to the drugs. This reaction sets in motion a pattern that "teaches" people to repeat the behavior of abusing drugs.
As a person continues to abuse drugs, the brain adapts to the overwhelming surges in dopamine by producing less dopamine or by reducing the number of dopamine receptors in the reward circuit. As a result, dopamine's impact on the reward circuit is lessened, reducing the abuser's ability to enjoy the drugs and the things that previously brought pleasure. This decrease compels those addicted to drugs to keep abusing drugs in order to attempt to bring their dopamine function back to normal. And, they may now require larger amounts of the drug than they first did to achieve the dopamine high—an effect known as tolerance.
Long-term abuse causes changes in other brain chemical systems and circuits as well. Glutamate is a neurotransmitter that influences the reward circuit and the ability to learn. When the optimal concentration of glutamate is altered by drug abuse, the brain attempts to compensate, which can impair cognitive function. Drugs of abuse facilitate nonconscious (conditioned) learning, which leads the user to experience uncontrollable cravings when they see a place or person they associate with the drug experience, even when the drug itself is not available. Brain imaging studies of drug-addicted individuals show changes in areas of the brain that are critical to judgment, decisionmaking, learning and memory, and behavior control. Together, these changes can drive an abuser to seek out and take drugs compulsively despite adverse consequences—in other words, to become addicted to drugs.
From the Doctors at MedicineNet.com
Drugs are chemicals that tap into the brain's communication system and disrupt the way nerve cells normally send, receive, and process information. There are at least two ways that drugs are able to do this: (1) by imitating the brain's natural chemical messengers, and/or (2) by overstimulating the "reward circuit" of the brain.
Some drugs, such as marijuana and heroin, have a similar structure to chemical messengers, called neurotransmitters, which are naturally produced by the brain. Because of this similarity, these drugs are able to "fool" the brain's receptors and activate nerve cells to send abnormal messages.
Other drugs, such as cocaine or methamphetamine, can cause the nerve cells to release abnormally large amounts of natural neurotransmitters, or prevent the normal recycling of these brain chemicals, which is needed to shut off the signal between neurons. This disruption produces a greatly amplified message that ultimately disrupts normal communication patterns.
Nearly all drugs, directly or indirectly, target the brain's reward system by flooding the circuit with dopamine. Dopamine is a neurotransmitter present in regions of the brain that control movement, emotion, motivation, and feelings of pleasure. The overstimulation of this system, which normally responds to natural behaviors that are linked to survival (eating, spending time with loved ones, etc), produces euphoric effects in response to the drugs. This reaction sets in motion a pattern that "teaches" people to repeat the behavior of abusing drugs.
As a person continues to abuse drugs, the brain adapts to the overwhelming surges in dopamine by producing less dopamine or by reducing the number of dopamine receptors in the reward circuit. As a result, dopamine's impact on the reward circuit is lessened, reducing the abuser's ability to enjoy the drugs and the things that previously brought pleasure. This decrease compels those addicted to drugs to keep abusing drugs in order to attempt to bring their dopamine function back to normal. And, they may now require larger amounts of the drug than they first did to achieve the dopamine high—an effect known as tolerance.
Long-term abuse causes changes in other brain chemical systems and circuits as well. Glutamate is a neurotransmitter that influences the reward circuit and the ability to learn. When the optimal concentration of glutamate is altered by drug abuse, the brain attempts to compensate, which can impair cognitive function. Drugs of abuse facilitate nonconscious (conditioned) learning, which leads the user to experience uncontrollable cravings when they see a place or person they associate with the drug experience, even when the drug itself is not available. Brain imaging studies of drug-addicted individuals show changes in areas of the brain that are critical to judgment, decisionmaking, learning and memory, and behavior control. Together, these changes can drive an abuser to seek out and take drugs compulsively despite adverse consequences—in other words, to become addicted to drugs.
From the Doctors at MedicineNet.com
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